Prof. Dr. Angela Casini

Prof. Dr. Angela Casini

Chair of Medical and Bioinorganic Chemistry

Which research topics are you focused on in your working group?

Our research covers inorganic, bioinorganic, and medicinal chemistry. The investigation of the role of metal ions in biological systems and the mechanisms of action of metal-based drugs are the focus of our research. Tailor-made metal compounds targeting selected biomolecules (proteins and nucleic acids) are produced and optimized in order to perform bioorthogonal transformations with target structures in an aqueous environment in the so-called “metal-templated reactions” and finally to enable catalysis in biological systems.

How is the schedule and content of a research internship designed at your working group?

The duration of the research internship is approximately 6 weeks, including the time for writing a report.

Which synthetical methods are used for the respective topics?

In addition to synthetic coordination chemistry and organometallic chemistry, our research focuses on an intensive biological/biophysical evaluation of the new compounds as experimental cytostatics, as well as on elucidating their mechanisms of action at the molecular level.

Is a progress/final talk about the research internship planned?

The student will present his/her research progress during the weekly group sessions. At the end of the internship, a PowerPoint presentation will be given summarizing the project goals and results.

With which working groups are overlapping topics possible?

Possible interdisciplinary projects are conceivable with the chair of Prof. Roland Fischer (supramolecular chemistry for biomedical applications), with Prof. Stefan Sieber (development of new antibacterial agents), and with Prof. Fritz Kühn (design and synthesis of organometallic drugs).

How and in what way can one apply for a research internship at your working group?

Students can apply for the research internship directly via an e-mail to Prof. Casini.

What kind of previous knowledge is required for a research internshipat your working?

Background knowledge and experience in inorganic, organic, and organometallic synthesis are highly recommended.

Can a research intership be expanded to a master’s thesis?

Yes, each internship is related to a broader project and could be developed into a master thesis.

How much cake does your chair expect?

Only 1, but a very good one!

Is it an advantage of small working groups, that there is more cake for everyone?

As long as Prof. Casini does not have to bake, yes!